Publication de Nicole Delepine : Treatment of advanced pelvic osteosarcoma with chemotherapy directly inside the tumor.

Nicole delépine, le site officiel English Version Version Française
Accueil Site officiel ACCUEIL
Accueil du site officiel de Nicole Delepine
publication cancérologue réputé nicole delepine ostéosarcome
sarcome ewing publications du docteur nicole delepine
Publié sur : International Workshop on brain. Bone and soft tissue Tumors. Paris - 2003
Voir la version PDF de cette publication : Document PDF
Treatment of advanced pelvic osteosarcoma with chemotherapy directly inside the tumor.
E.Guikov, S.Alkallaf, B.Markowska, H.Cornille, I.M.Bigirimana, G.Delépine, Nicole Delépine

Treatment of advanced pelvic osteosarcoma with chemotherapy directly inside the tumor.



Case report - Introduction


Very large tumors of pelvis often seem inoperable and are treated by palliative radiotherapy and/or chemotherapy.
We present here a case with intratumoral chemotherapy and mid-term result.

This girl, 16 years old


She came from Africa in 2000 July, for a huge tumor of pelvis after 2 years of pelvic pain.
tumor of pelvis


August 2000. needle biopsy


tumor of pelvis

The biopsy confirmed the diagnosis of high grade osteosarcoma.
No distant metastase was seen on bone and scan.

Conventional chemotherapy didn't obtain any objective response.


tumor of pelvis chemotherapy

As no carcinologic surgery seemed possible the patient was sent in a palliative care unit after 2 months of an ineffective treatment.

October 2000 she came to our unit.


huge tumor

Initial screening showed a huge tumor (15 cm x 12 x 10) developed from the right acetabulum, with compression of bladder and ureters.

October 2000


huge tumor

After intratumoral currettage we started both general and local chemotherapy infused directly inside the tumor cavity through an infusion catheter.

Both intra-tumor and intravenous chemotherapy were continued


intravenous chemotherapy

We observed an impressive tumoral schrinkage (75% of initial tumoral volume) new debulking surgery was performed and the urinary tract could be repaired.

October 2001


composite acetabular reconstruction

The last tumor residual was removed and a composite acetabular reconstruction performed.

One year after surgery the hip function rated according to Ennecking's criteria is excellent


Ennecking's criteria is excellent


Oncologic Result


Oncologic Result

In april 2003, 30 months after she was considered to have a life expectancy less than 1 month ,the patient is in complete remission.
She can walk, go to school and live normally.

Conclusion


Advanced sarcoma can sometimes benefit of an individualized treatment including intratumoral chemotherapy.

"les seuls combats perdus d'avance sont ceux qu'on ne livre pas"




publications médicales


sarcome d'ewing
nicole delepine cancer tumeur ostéosarcome
Facebook Tweeter Google+