Publication de Nicole Delepine : Very late recurrence of Ewing sarcoma (ES): Report on three cases and review of literature

Nicole delépine, le site officiel English Version Version Française
Accueil Site officiel ACCUEIL
Accueil du site officiel de Nicole Delepine
publication cancérologue réputé nicole delepine ostéosarcome
sarcome ewing publications du docteur nicole delepine
Publié sur : Journal of Clinical Oncology 29 (suppl. Abstract N°20005) - 2011
Voir la version PDF de cette publication : Document PDF | Publication sur le site du média : Document www
Very late recurrence of Ewing sarcoma (ES): Report on three cases and review of literature
H.Cornille, S.Alkhallaf, G.Delepine, Nicole Delepine

Very late recurrence of Ewing sarcoma (ES): Report on three cases and review of literature.


Pediatric Oncology / Pediatric Solid Tumors


2011 ASCO Annual Meeting


This abstract will not be presented at the 2011 ASCO Annual Meeting but has been published in conjunction with the meeting.

Abstract:


Background:
ES is the second malignant bone tumour in children and young adults. Most relapses occur the first years following the diagnosis. We report 3 very late ES recurrence (11, 20, 24 y after primary tumour). 2 occurred a long time after a first relapse.

Methods:
P 1: In 1991 a 21 y old girl was treated for tibia non metastatic ES by neo and adjuvant chemotherapy, extra-tumoral surgery. Tumour necrosis (TN) was 100%. In 2002 after local trauma, she had a first local relapse. She remained 3 y in remission, after second line of treatment included complete surgery. She died in 2007, after a second local recurrence, in spite of contaminated surgery, chemotherapy and radiotherapy.
P 2: In 1990 an11 y old boy was treated for superior femoral ES by neoadjuvant chemotherapy, surgery. TN was 93%. Parents refused adjuvant chemotherapy. In 1993, he presented a first inguinal local relapse treated by neo and adjuvant chemotherapy, partial surgery, local radiotherapy. TN was 5%. In June 2010, 17 years after the first relapse, he presented a sacral metastasis and one isolated pulmonary metastasis; he was treated by chemotherapy and sacral radiotherapy. He is still in treatment, with stable pulmonary and no evolutive sacral disease.
P 3: In 1986, a ten y old girl was treated for L3 non metastatic ES by neoadjuvant and adjuvant chemotherapy, contaminated surgery. TN was 100%. She didn't have radiotherapy. In January 2011, 7 and 9 years after 2 pregnancies, she had local relapse Diagnosis was delayed for 3 months after erroneous interpretation of symptoms.

Results:
In Rizzoli experience of ES outcome, patients who relapse after combined treatment is very poor. However, when the relapse is late, patients seem to be more receptive to traditional treatment and outcome better. Dubois reported in 2008, 2 ES late relapses during pregnancy.

Conclusions:
These cases pointed out the need to remain vigilant for ES, a long time after diagnosis. Late relapses must be envisaged as a cause of symptoms, to avoid diagnosis delay.





publications médicales


sarcome d'ewing
nicole delepine cancer tumeur ostéosarcome
Facebook Tweeter Google+