Publication de Nicole Delepine : Pronostic value of initial management in localized osteosarcoma. A monocentric retrospective analysis.

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Publié sur : ECCO 11 - Lisbon, Portugal - The european cancer conference - 2001
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Pronostic value of initial management in localized osteosarcoma. A monocentric retrospective analysis.
F. Delepine, G. Delepine, Nicole Delepine

Pronostic value of initial management in localized osteosarcoma. A monocentric retrospective analysis.



Introduction


Many reports attempt to identify the factors which may affect the prognosis in osteosarcoma. We wanted to determine whether the technique of biopsy and/or the initial management could be prognostic factor of long term survival.

Patients


139 patients (88 males and 51 females aged 4-58 years) with localized osteosarcomas of the limbs were treated and/or followed up by our team between 1984 and 1998.

osteosarcoma


Initial management of Patients 1


osteosarcoma


1) Local screening
2) Planning the resection
3) Choose the biopsy approach
4) Short straight incision
55 first hand patients had the biopsy performed by the surgeon of the team after local evaluation of the tumor and planning of future en bloc resection.

Initial management of Patients 2


osteosarcoma

The 84 other patients were referred to us after biopsy or/and induction therapy.

Initial prognostic factors


No significant differences in initial prognosis factors were observed between the two groups.

Method


All patients received preoperative and postoperative chemotherapy according to the current protocols at the time of their treatment.

3 patients were primarily amputated


All for initial inadapted biopsy.
osteosarcoma


Local treatment


The 136 other patients were treated by limb salvage even for fractured or huge tumors and in very young patients.

osteosarcoma


Follow up protocol


All patients were follow up by their surgeon and their chemotherapist every 3 months during 2 years, then every 6 months for 2 other years and yearly thereafter.
median follow is 10 years
(maximal 16 - minimal 2)

Local recurrence risk


osteosarcoma


Disease free survival


54 % (46/84) of referred patients are alive in remission compared to 73% (40/55) of first hand patients (93% for first hand patients treated by our protocols since 1/1986).

Actuariel Disease free survival


osteosarcoma


Conclusion


Initial management by an experimented team is of crucial importance in long term survival of patients with localized osteosarcoma of the limb.

When the diagnosis of osteosarcoma can not be excluded on prebiopsy medical imaging of bone tumor, patient should be referred before biopsy, to team experimented in bone tumor oncology.


The Hazards of the biopsy :
Inadequate biopsies : 17.8%
10.1% loss of disease free expectancy.
3% patients had to be amputated has a consequence of inadapted biopsy.
No progress has been seen when comparing to the comparative study perform in 1982 ????
The Hazards of the biopsy.Revisited. Mankin H.J..J BJS 1996,78A 5




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