Publication de Nicole Delepine : Pharmacokinetics of Ifosfamide and metabolites

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Publié sur : Publication Powerpoint Nicole Delépine - 2001
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Pharmacokinetics of Ifosfamide and metabolites
B. Gourmel, S. Denis, Nicole Delépine

Pharmacokinetics of Ifosfamide and metabolites



Ifosfamide


4 OH IFOS


Continuous infusion in Children (3g/m²/d)



Continuous infusion


Continuous infusion II


Observation of Ifosfamide


Concentration and A.U.C of Ifosfamide and metabolites



Concentration and AUC of IFOS


IFOS metabolites whole in blood level during 4 days infusion



Whole blood level for 4 days infusion


3d IFOS


4 OH IFSOS



Pharmacokinetic



Pharmacokinetic profiles of ifosfamide during a 5 days continuous infusion of ifosfamide (Values are dose corrected) in 7 patients.

Pharmacokinetic of IFOS


Variation of the metabolite index of 2D Ifos



2d IFOS


Variation of the metabolite index of 3D Ifos



3d IFOS


Variation of the metabolite index of 4 Hydroxy Ifos



4 OH IFOS


Pharmacokinetic profiles of 4 Hydroxy ifosfamide during a 5 days continuous infusion of ifosfamide in 7 patients.



Pharmacokinetic OF 4 OH IFOS


Aziridium


monoadduct




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